Rifkin A, Wortman R, Reardon G, Siris S G
J Clin Psychiatry. 1986 Aug;47(8):400-8.
All published articles of double-blind, controlled studies of drug treatment of mental disorders in adolescents are reviewed. The evidence for efficacy ranges from suggestive to nonexistent, without any match of drug and disorder showing definitive evidence, either because of the limited number of studies available or because these studies have less than clear findings. Special considerations in the study of adolescent psychopharmacology are addressed, and a practical approach to drug treatment making the best use of the limited information available is offered.
对所有已发表的关于青少年精神障碍药物治疗的双盲对照研究文章进行了综述。疗效证据从暗示性到不存在,没有任何药物与疾病的匹配显示出确凿证据,这要么是因为可用研究数量有限,要么是因为这些研究的结果不够明确。文中讨论了青少年精神药理学研究中的特殊考虑因素,并提供了一种利用有限可用信息进行药物治疗的实用方法。