van Jaarsveld Richard H, Kops Geert J P L
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584 CT Utrecht, The Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584 CT Utrecht, The Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG, Utrecht, The Netherlands.
Trends Cancer. 2016 Oct;2(10):561-571. doi: 10.1016/j.trecan.2016.09.003. Epub 2016 Sep 24.
Human cancers harbor great numbers of genomic alterations. One of the most common alterations is aneuploidy, an imbalance at the chromosome level. Some aneuploid cancer cell populations show varying chromosome copy number alterations over time, a phenotype known as 'chromosomal instability' (CIN). Chromosome segregation errors in mitosis are the most common cause for CIN in vitro, and these are also thought to underlie the aneuploidies seen in clinical cancer samples. However, CIN and aneuploidy are different traits and they are likely to have distinct impacts on tumor evolution and clinical tumor behavior. In this opinion article, we discuss these differences and describe scenarios in which distinguishing them can be clinically relevant.
人类癌症存在大量基因组改变。最常见的改变之一是非整倍体，即染色体水平的失衡。一些非整倍体癌细胞群体随时间显示出不同的染色体拷贝数改变，这种表型称为“染色体不稳定性”（CIN）。有丝分裂中的染色体分离错误是体外CIN的最常见原因，并且这些也被认为是临床癌症样本中所见非整倍体的基础。然而，CIN和非整倍体是不同的特征，它们可能对肿瘤演变和临床肿瘤行为有不同的影响。在这篇观点文章中，我们讨论了这些差异，并描述了区分它们可能具有临床相关性的情况。
