Shabankarehfard Elham, Ostovar Afshin, Farrokhi Shokrollah, Naeimi Behrouz, Zaeri Sasan, Nazmara Shahrokh, Keshtkar Mozhgan, Sadeghzadeh Farzaneh, Dobaradaran Sina
a Department of Environmental Health Engineering , Faculty of Health, Bushehr University of Medical Sciences , Bushehr , Iran.
b Department of Infectious Diseases, The Persian Gulf Tropical Medicine Research Center , The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences , Bushehr , Iran.
Immunol Invest. 2017 Aug;46(6):577-589. doi: 10.1080/08820139.2017.1322102. Epub 2017 Jul 25.
Despite the recent increases in fungi-induced allergic diseases, there is no report yet in the region of the Persian Gulf on concentration levels of fungi in relationship with health state. Therefore, our aim was to measure fungi prevalence as well as to evaluate the relationships between air- and dust-borne fungal genera and allergic diseases. A matched case-control study was carried out including 45 allergic cases and 45 age- and gender-matched controls for each individual. Indoor and outdoor dust and indoor air samples were collected from participant homes during May to October 2015. A Quick Take 30 Pump and sterile wet swab were used to determine fungal types and their amounts in the air (CFU/m) and dust (CFU/100 cm) samples, respectively. A significant reverse association was found between indoor dust-borne Alternaria and asthma (Odds ratio (OR) = 0.14, 95% CI = 0.02-0.86). Contrarily, increased levels of indoor air-borne Aspegillus fumigatus (OR = 2.00, 95% CI = 0.37-10.55) and Alternaria (OR = 3.00, 95% CI = 0.34-25.83) were correlated with asthma development. Also, correlation analysis showed a significant relation between indoor air-borne Penicillium levels and reactivity to skin prick test in asthmatic patients (p = 0.04). Our findings support the notion that fungal exposures can either cause or prevent the development of allergic diseases. Accordingly, appropriate measures should be taken for a better management of fungi-induced allergic diseases.
尽管最近真菌引起的过敏性疾病有所增加，但波斯湾地区尚未有关于真菌浓度水平与健康状况关系的报告。因此，我们的目的是测量真菌的流行情况，并评估空气传播和灰尘传播的真菌属与过敏性疾病之间的关系。我们进行了一项匹配的病例对照研究，包括45例过敏病例以及为每个个体匹配的45例年龄和性别相匹配的对照。在2015年5月至10月期间，从参与者家中采集室内和室外灰尘以及室内空气样本。分别使用Quick Take 30泵和无菌湿拭子来确定空气样本（CFU/m）和灰尘样本（CFU/100 cm）中的真菌类型及其数量。发现室内灰尘中的链格孢属与哮喘之间存在显著的负相关（比值比（OR）= 0.14，95%置信区间 = 0.02 - 0.86）。相反，室内空气中烟曲霉（OR = 2.00，95%置信区间 = 0.37 - 10.55）和链格孢属（OR = 3.00，95%置信区间 = 0.34 - 25.83）水平的升高与哮喘的发展相关。此外，相关性分析显示哮喘患者室内空气中青霉属水平与皮肤点刺试验反应性之间存在显著关系（p = 0.04）。我们的研究结果支持这样一种观点，即接触真菌既可能导致也可能预防过敏性疾病的发展。因此，应采取适当措施以更好地管理真菌引起的过敏性疾病。
