Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Shaanxi, People's Republic of China.
Obes Rev. 2017 Nov;18(11):1260-1271. doi: 10.1111/obr.12590. Epub 2017 Jul 25.
Obesity is one of the most serious global public health challenges of the 21st century. The adjustment of gut microbiota is often recommended as an efficient strategy to treat obesity. This modulation of gut microbiota can be performed by many methods, including dietary intervention, antibiotic application, the use of prebiotics and probiotics, bariatric surgery and faecal microbiota transplantation. In most cases, positive effects have been observed in response to treatment, but invalid and even contrary effects have also been observed in some cases due to factors that are unrelated to intervention methods, such as genetic factors, patient age or gender, environmental microbiota, climate, geography and lifestyle. These factors can cause variation of gut microbial populations and thus should also be taken into consideration when selecting modulation strategies.
肥胖是 21 世纪全球面临的最严峻的公共卫生挑战之一。肠道微生物群的调节常被推荐作为治疗肥胖的有效策略。这种肠道微生物群的调节可以通过多种方法来实现，包括饮食干预、抗生素的应用、使用益生元和益生菌、减重手术和粪便微生物群移植。在大多数情况下，治疗后观察到了积极的效果，但也有一些情况下由于与干预方法无关的因素，如遗传因素、患者年龄或性别、环境微生物群、气候、地理和生活方式等，观察到了无效甚至相反的效果。这些因素可能导致肠道微生物群的变化，因此在选择调节策略时也应考虑这些因素。
