He Liuyang, Zheng Jianzhou, Xia Lei, Qi Chunjian, Wang Yong, Yang Mingxia
Institute of Heart, Lung and Blood Vessel Diseases, Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu, China (He LY, Zheng JZ, Xia L, Wang Y, Yang MX); Central Laboratory, Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu, China (He LY, Zheng JZ, Xia L, Qi CJ); Department of Respiratory and Critical Care Medicine, Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu, China (Yang MX). Corresponding author: Yang Mingxia, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017 Jul;29(7):651-655. doi: 10.3760/cma.j.issn.2095-4352.2017.07.017.
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an inflammatory lung injury induced by a variety of factors, and these diseases are associated with high rates of mortality due to the lack of effective treatments. Based on the latest research in ALI/ARDS, it is widely accepted that generalized inflammatory responses play a critical role in initiating and developing process of ALI/ARDS. We make a brief review on the immune-pathogenesis and the signaling pathways of ALI/ARDS from the perspective of inflammation, thereby helping develop novel therapeutic strategy for treatment of patients with ALI/ARDS.
急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）是由多种因素引起的炎症性肺损伤，由于缺乏有效的治疗方法，这些疾病的死亡率很高。基于对ALI/ARDS的最新研究，普遍认为全身性炎症反应在ALI/ARDS的启动和发展过程中起关键作用。我们从炎症的角度对ALI/ARDS的免疫发病机制和信号通路进行简要综述，从而有助于开发治疗ALI/ARDS患者的新型治疗策略。
