Yang Cheng-Mei, Chen Chien-Chou, Tseng Yu-Kai, Huang Sin-Jhih, Liou Huei-Han, Lee Yi-Cheng, Lee Jang-Hwa, Wang Jyh-Seng, Chen Hung-Chih, Chi Chao-Chuan, Kang Bor-Hwang, Lin Yun-Chung, Tsai Kuo-Wang, Ger Luo-Ping
Director, Division of Endodontics, Department of Stomatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Assistant Professor, Department of Dental Technology, Shu-Zen Junior College of Medicine and Management, Kaohsiung, Taiwan.
Director, Department of Family Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Oct;124(4):378-389.e1. doi: 10.1016/j.oooo.2017.05.515. Epub 2017 Jun 8.
This case-control study evaluated the association of the single nucleotide polymorphism rs7372209 (T>C) in pri-mir-26a-1 with the risk and progression of betel quid (BQ)-related oral premalignant lesions (OPLs) and oral squamous cell carcinoma (OSCC).
In total, 597 BQ chewers were recruited: 196 healthy controls, 241 patients with OPLs, and 160 patients with OSCC. Genotypes were determined using the TaqMan real-time assay.
The C/T + T/T genotypes and T allele in pri-mir-26a-1 were correlated with a decreased risk of BQ-related OPLs (P = .038 and .005, respectively), oral leukoplakia (P = .01 and .001, respectively), and advanced-stage OSCC (P = .021 and .004, respectively). The effects of the C/T + T/T genotypes and T allele on the decreased risk of OPLs were potent in the older age group (both P < .001), heavy smokers (P ≤ .003 and .006, respectively) and alcohol drinkers (P ≤ .004 and .001, respectively). Furthermore, among patients with OSCC, the C/T + T/T genotypes and T allele were associated with a decreased risk of advanced pathologic stage (P = .032) and lymph node involvement (P = .017).
BQ chewers carrying the T allele or C/T + T/T genotypes in pri-mir-26a-1 may have a decreased risk of oral leukoplakia, OPLs, and advanced-stage OSCC.
本病例对照研究评估了前体微小RNA-26a-1（pri-mir-26a-1）中的单核苷酸多态性rs7372209（T>C）与槟榔相关口腔癌前病变（OPL）和口腔鳞状细胞癌（OSCC）的风险及进展之间的关联。
共招募了597名槟榔咀嚼者，其中196名健康对照者、241名OPL患者和160名OSCC患者。采用TaqMan实时检测法确定基因型。
pri-mir-26a-1中的C/T + T/T基因型和T等位基因与槟榔相关OPL风险降低相关（分别为P = 0.038和0.005）、口腔白斑（分别为P = 0.01和0.001）以及晚期OSCC（分别为P = 0.021和0.004）。C/T + T/T基因型和T等位基因对降低OPL风险的影响在老年组中显著（均P < 0.001）、重度吸烟者中（分别为P≤0.003和0.006）以及饮酒者中（分别为P≤0.004和0.001）。此外，在OSCC患者中，C/T + T/T基因型和T等位基因与晚期病理分期风险降低相关（P = 0.032）以及淋巴结受累风险降低相关（P = 0.017）。
携带pri-mir-26a-1中T等位基因或C/T + T/T基因型的槟榔咀嚼者患口腔白斑、OPL和晚期OSCC的风险可能降低。
