Department of Metabolism, Endocrinology and Molecular Medicine, and Department of Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kidney Center, Shirasagi Hospital, Osaka, Japan.
Sci Rep. 2017 Jul 25;7(1):6434. doi: 10.1038/s41598-017-06850-4.
The negative relation of serum adiponectin to atherosclerosis becomes a positive association in patients with chronic kidney disease (CKD). We conducted a small-scale cross-sectional observational study, in 101 Japanese male hemodialysis patients, to examine the relationship of serum adiponectin and leptin to abdominal aortic calcification (AAC). The presence of AAC was evaluated from simple X-ray radiographs of the left lateral abdomen. Serum adiponectin was significantly higher in AAC-positive patients [18.8 (13.0-28.1) μg/mL] than in AAC-negative patients [15.4 (8.9-22.8) μg/mL] (p = 0.03), whereas serum leptin did not differ significantly between the two groups. Multiple logistic regression analysis showed that log adiponectin, but not log leptin, was independently and significantly associated in a positive manner with AAC (odds ratio: 16.31, 95% confidence interval: 1.70-156.41, p = 0.02), after adjustment for age, body weight, percentage body fat, hemodialysis duration, prevalence of diabetes mellitus, and other risk factors. In conclusion, we found a positive and independent association of serum adiponectin with AAC in male hemodialysis patients, indicating that the reversed association between serum adiponectin and atherosclerosis in patients with CKD dose not result from increased serum adiponectin due to the impaired urinary secretion.
血清脂联素与动脉粥样硬化的负相关在慢性肾脏病（CKD）患者中变为正相关。我们进行了一项小规模的横断面观察性研究，纳入了 101 名日本男性血液透析患者，以研究血清脂联素和瘦素与腹主动脉钙化（AAC）的关系。AAC 的存在通过左外侧腹部的简单 X 射线评估。AAC 阳性患者的血清脂联素水平显著高于 AAC 阴性患者[18.8（13.0-28.1）μg/mL]（p=0.03），而两组间血清瘦素水平无显著差异。多变量逻辑回归分析显示，在调整年龄、体重、体脂百分比、血液透析时间、糖尿病患病率和其他危险因素后，log 脂联素与 AAC 呈独立且显著正相关（比值比：16.31，95%置信区间：1.70-156.41，p=0.02）。综上所述，我们发现男性血液透析患者血清脂联素与 AAC 呈正相关且独立相关，表明 CKD 患者血清脂联素与动脉粥样硬化之间的反向关联并非由于尿排泄受损导致血清脂联素增加所致。
