Department of Endocrinology, Aalborg University Hospital, Mølleparkvej 4, 9220, Aalborg Øst, Denmark.
Faculty of Health, Aalborg University, Niels Jernes Vej 10, 9220, Aalborg Øst, Denmark.
Curr Osteoporos Rep. 2018 Feb;16(1):42-57. doi: 10.1007/s11914-018-0418-z.
A systematic literature review was performed to evaluate diabetes mellitus (DM) as a risk factor of abdominal aortic calcification (AAC), and address factors that might contribute to the development of AAC in DM patients.
DM is an independent risk factor of AAC development. Bone metabolism along with lifestyle factors among DM patients makes them more prone to AAC. Hip and vertebral fractures, high phosphate, smoking, hypertension, and low osteocalcin could make DM patients prone to AAC. Low levels of high-density lipoprotein (HDL), high low-density lipoprotein (LDL), high total cholesterol/HDL ratio, low bone mineral density (BMD) may be risk factors, but the literature is more ambiguous. Body mass index (BMI) does not appear to increase risk of AAC. High phosphate levels and low osteocalcin levels seem to be biomarkers of AAC in patients with diabetes. However, the association between DM and AAC is complicated.
系统文献回顾评估了糖尿病（DM）作为腹主动脉钙化（AAC）的危险因素，并探讨了可能导致 DM 患者发生 AAC 的因素。
DM 是 AAC 发展的独立危险因素。DM 患者的骨代谢和生活方式因素使他们更容易发生 AAC。髋部和脊椎骨折、高磷血症、吸烟、高血压和低骨钙素使 DM 患者易发生 AAC。高密度脂蛋白（HDL）水平低、低密度脂蛋白（LDL）水平高、总胆固醇/HDL 比值高、骨密度（BMD）低可能是危险因素，但文献报道较为模糊。体重指数（BMI）似乎不会增加 AAC 的风险。高磷血症和低骨钙素水平似乎是糖尿病患者 AAC 的生物标志物。然而，DM 和 AAC 之间的关联很复杂。
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