Department of Orthopedics, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.
Department of Endocrinology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, 318000, Zhejiang, China.
Clin Rheumatol. 2024 Sep;43(9):2955-2961. doi: 10.1007/s10067-024-07081-5. Epub 2024 Jul 26.
Diabetes mellitus (DM) and gout cohabitation severely reduces patient life quality while raising financial burden on individual and society. The aim of this study was to elucidate the association between physical activity (PA) and the prevalence of gout among type 2 DM (T2DM) and hyperuricemia (HUA) patients.
In all, we recruited 2291 T2DM patients with HUA. Among them, 448 had gout and 1843 did not. We collected patient data, such as anthropometry, laboratory reports, and medical history, for our analyses. The PA assessment was based on the Chinese version of International PA Questionnaire-short (IPAQ). Moreover, the relationship between PA and gout risk was examined using multivariate logistic regression models.
Total PA was markedly low among gout patients, relative to controls (p < 0.05). Based on the IPAQ categorical score, 38.2% exhibited "low," 26.8% "moderate," and 35.0% "high" PA among gout patients. In comparison, 12.4% performed "low," 53.8% "moderate," and 33.8% "high" PA among controls. Multivariate analysis revealed that, after adjustment of confounding factors, both low (OR 6.382) and high PA (OR 2.048) had a higher prevalence of gout, as compared to moderate PA. Moreover, we revealed that the male sex, age, HUA duration, serum uric acid, glycated hemoglobin, dyslipidemia history, and drinking status were also independent indicators of the prevalence of gout. Furthermore, stratification analyses revealed results consistent with our prior results.
PA intensity was associated with the prevalence of gout among T2DM and HUA patients, and the lowest prevalence was achieved from moderate intensity PA. Key Points • PA intensity was associated with the prevalence of gout among T2DM and HUA patients. • The lowest prevalence of gout was achieved from moderate intensity PA.
糖尿病（DM）和痛风共存会严重降低患者的生活质量，同时增加个人和社会的经济负担。本研究旨在阐明体力活动（PA）与 2 型糖尿病（T2DM）和高尿酸血症（HUA）患者痛风患病率之间的关系。
共纳入 2291 例 HUA 的 T2DM 患者。其中，448 例患有痛风，1843 例未患有痛风。我们收集了患者的人体测量学、实验室报告和病史等数据进行分析。PA 评估基于中文版国际体力活动问卷（IPAQ）。此外，还使用多变量 logistic 回归模型检查了 PA 与痛风风险之间的关系。
痛风患者的总 PA 明显低于对照组（p<0.05）。根据 IPAQ 分类评分，痛风患者中 38.2%表现为“低”、26.8%为“中”、35.0%为“高”PA。相比之下，对照组中分别有 12.4%、53.8%和 33.8%为“低”、“中”和“高”PA。多变量分析显示，在调整混杂因素后，与中强度 PA 相比，低强度（OR 6.382）和高强度 PA（OR 2.048）痛风的患病率更高。此外，我们还发现男性、年龄、HUA 持续时间、血清尿酸、糖化血红蛋白、血脂异常史和饮酒状态也是痛风患病率的独立指标。此外，分层分析结果与我们的初步结果一致。
PA 强度与 T2DM 和 HUA 患者痛风患病率相关，中等强度 PA 可使痛风患病率最低。关键点• PA 强度与 T2DM 和 HUA 患者痛风患病率相关。• 中等强度 PA 可使痛风患病率最低。
