用于脑肿瘤协同治疗的快速MRI可追踪凝胶形成双药递送系统
Rapid MRI Traceable Gel-forming Dual-drug Delivery for Synergistic Therapy of Brain Tumor.
作者信息
Lin Feng-Wei, Chen Pin-Yuan, Wei Kuo-Chen, Huang Chiung-Yin, Wang Chih-Kuang, Yang Hung-Wei
机构信息
Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.
Department of Neurosurgery, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
出版信息
Theranostics. 2017 Jun 25;7(9):2524-2536. doi: 10.7150/thno.19856. eCollection 2017.
Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogel/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.
脑肿瘤手术切除后预防肿瘤复发是一项重大的临床挑战，因为目前的方法以快速的方式递送化疗药物，且对残留肿瘤细胞无效。为克服这一缺点，我们报告了一种简单的方法，可制备具有磁共振成像（MRI）可追踪性的超热敏水凝胶，该水凝胶在28°C下能在4秒内从水溶液中快速凝胶化，用于与牛血清白蛋白纳米颗粒（BSA NPs）结合共递送亲水性药物（表柔比星，EPI）和疏水性药物（紫杉醇，PTX）。结果显示，接受掺入BSA/PTX NPs的水凝胶/EPI的荷胶质肉瘤（MBR 614或U87）小鼠的平均生存期延长至63天或69天，且未观察到肿瘤复发。我们的协同策略为开发预防脑肿瘤复发的局部药物递送系统提供了一种新方法。
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