利用迈克尔型加成反应设计硫醇和光敏感可降解水凝胶
Design of Thiol- and Light-sensitive Degradable Hydrogels using Michael-type Addition Reactions.
作者信息
Kharkar Prathamesh M, Kiick Kristi L, Kloxin April M
机构信息
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA.
Department of Materials Science and Engineering, University of Delaware, Newark, DE 19716, USA ; Department of Biomedical Engineering, University of Delaware, Newark, DE 19716, USA ; Delaware Biotechnology Institute, University of Delaware, Newark, DE 19716, USA.
出版信息
Polym Chem. 2015 Aug 21;6(31):5565-5574. doi: 10.1039/C5PY00750J.
Injectable depots that respond to exogenous and endogenous stimuli present an attractive strategy for tunable, patient-specific drug delivery. Here, the design of injectable and multimodal degradable hydrogels that respond to externally applied light and physiological stimuli, specifically aqueous and reducing microenvironments, is reported. Rapid hydrogel formation was achieved using a thiol-maleimide click reaction between multifunctional poly(ethylene glycol) macromers. Hydrogel degradation kinetics in response to externally applied cytocompatible light, reducing conditions, and hydrolysis were characterized, and degradation of the gel was controlled over multiple time scales from seconds to days. Further, tailored release of an encapsulated model cargo, fluorescent nanobeads, was demonstrated.
可响应外源性和内源性刺激的注射剂储存库为可调谐、针对患者的药物递送提供了一种有吸引力的策略。在此，报道了一种可注射的多模态可降解水凝胶的设计，该水凝胶可响应外部施加的光和生理刺激，特别是水性和还原性微环境。通过多功能聚乙二醇大分子单体之间的硫醇-马来酰亚胺点击反应实现了水凝胶的快速形成。对响应外部施加的细胞相容性光、还原条件和水解的水凝胶降解动力学进行了表征，并且凝胶的降解在从秒到天的多个时间尺度上得到控制。此外，还展示了封装的模型货物荧光纳米珠的定制释放。
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