Stawicki Brielle, Schacher Tyler, Cho Hyunah
School of Pharmacy and Health Sciences, Fairleigh Dickinson University, 230 Park Ave., Florham Park, NJ 07932, USA.
Gels. 2021 May 26;7(2):63. doi: 10.3390/gels7020063.
Chemotherapy and radiation remain as mainstays in the treatment of a variety of cancers globally, yet some therapies exhibit limited specificity and result in harsh side effects in patients. Brain tissue differs from other tissue due to restrictions from the blood-brain barrier, thus systemic treatment options are limited. The focus of this review is on nanogels as local and systemic drug delivery systems in the treatment of brain cancer. Nanogels are a unique local or systemic drug delivery system that is tailorable and consists of a three-dimensional polymeric network formed via physical or chemical assembly. For example, thermosensitive nanogels show promise in their ability to incorporate therapeutic agents in nano-structured matrices, be applied in the forms of sprays or sols to the area from which a tumor has been removed, form adhesive gels to fill the cavity and deliver treatment locally. Their usage does come with complications, such as handling, storage, chemical stability, and degradation. Despite these limitations, the current ongoing development of nanogels allows patient-centered treatment that can be considered as a promising tool for the management of brain cancer.
化疗和放疗仍然是全球治疗多种癌症的主要手段，但一些疗法特异性有限，会给患者带来严重的副作用。由于血脑屏障的限制，脑组织与其他组织不同，因此全身治疗选择有限。本综述的重点是纳米凝胶作为治疗脑癌的局部和全身药物递送系统。纳米凝胶是一种独特的局部或全身药物递送系统，具有可定制性，由通过物理或化学组装形成的三维聚合物网络组成。例如，热敏纳米凝胶在将治疗剂纳入纳米结构基质方面显示出前景，可通过喷雾或溶胶的形式应用于肿瘤切除部位，形成粘性凝胶填充腔隙并进行局部治疗。其使用确实存在一些并发症，如处理、储存、化学稳定性和降解。尽管有这些局限性，但目前纳米凝胶的持续发展使以患者为中心的治疗成为可能，可被视为治疗脑癌的一种有前景的工具。
