Salimi Ahmad, Talatappe Behnaz Shoja, Pourahmad Jalal
Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Science, Ardabil, Iran.
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Toxicol Res. 2017 Jul;33(3):233-238. doi: 10.5487/TR.2017.33.3.233. Epub 2017 Jul 15.
Xylene is a cyclic hydrocarbon and an environmental pollutant. It is also used in medical technology, paints, dyes, polishes and in many industries as a solvent; therefore, an understanding of the interaction between xylene and human lymphocytes is of significant interest. Biochemical assessment was used to demonstrate that exposure of lymphocytes to xylene induces cytotoxicity (at 6 hr), generates intracellular reactive oxygen species, collapse of mitochondrial membrane potential, lysosomal injury, lipid peroxidation and depletion of glutathione (at 3 hr). The findings show that xylene triggers oxidative stress and organelle damage in lymphocytes. The results of our study suggest that the use of antioxidant, mitochondrial and lysosomal protective agents can be helpful for individuals subject to chronic exposure to xylene.
二甲苯是一种环状烃类，也是一种环境污染物。它还被用于医疗技术、油漆、染料、抛光剂以及许多行业作为溶剂；因此，了解二甲苯与人类淋巴细胞之间的相互作用具有重要意义。生化评估表明，淋巴细胞暴露于二甲苯会诱导细胞毒性（6小时时），产生活细胞内活性氧，导致线粒体膜电位崩溃、溶酶体损伤、脂质过氧化以及谷胱甘肽消耗（3小时时）。研究结果表明，二甲苯会引发淋巴细胞中的氧化应激和细胞器损伤。我们的研究结果表明，使用抗氧化剂、线粒体和溶酶体保护剂可能对长期接触二甲苯的个体有所帮助。
