Metsemakers W J, Claes G, Terryn P J, Belmans A, Hoekstra H, Nijs S
Department Development and Regeneration, KU Leuven-University of Leuven, B-3000, Louvain, Belgium.
Department of Trauma Surgery, University Hospitals Leuven, Herestraat 49, B-3000, Louvain, Belgium.
Eur J Trauma Emerg Surg. 2019 Feb;45(1):21-29. doi: 10.1007/s00068-017-0821-7. Epub 2017 Jul 25.
The management of segmental bone loss poses a significant clinical challenge. The purpose of this study was to conduct a retrospective evaluation of our experience in treating segmental bone loss, using Reamer-Irrigator-Aspirator (RIA)-harvested autologous bone graft.
Between June 2008 and March 2015, 81 patients were treated with the RIA technique for multiple purposes. Inclusion criteria for this study were skeletal mature patients with segmental bone loss, due to acute trauma or non-union, who were treated with RIA-harvested bone graft. Exclusion criteria were skeletal immaturity, pathological fractures and indications for the RIA system other than bone graft harvesting. The primary outcome parameter was clinical and radiographical bone healing.
During the study period, 72 patients met the inclusion criteria. In total, 39 patients (54.2%) were classified as having clinical and radiographical bone healing. Although univariate analysis could not reveal any significant influence of specific risk factors to predict the outcome, there was a trend towards statistical significance for defect volume. Further analysis indeed revealed that smaller defect volumes (< 8 cm) had a lower risk of non-union.
In approximately half of our study population, the use of the RIA technique for autologous bone graft harvesting in cases of segmental bone loss resulted in a successful outcome with bone healing. Defect size seems to be a critical issue regarding the outcome. Although our results are less promising than previously published, the RIA technique has its place in the treatment algorithm of segmental bone defects.
节段性骨缺损的治疗是一项重大的临床挑战。本研究的目的是对我们使用扩髓-冲洗-吸引(RIA)采集的自体骨移植治疗节段性骨缺损的经验进行回顾性评估。
2008年6月至2015年3月期间,81例患者因多种目的接受了RIA技术治疗。本研究的纳入标准为因急性创伤或骨不连导致节段性骨缺损的骨骼成熟患者,且采用RIA采集的骨移植进行治疗。排除标准为骨骼未成熟、病理性骨折以及除骨移植采集外RIA系统的其他适应证。主要结局参数为临床和影像学骨愈合情况。
在研究期间,72例患者符合纳入标准。总共有39例患者(54.2%)被归类为临床和影像学骨愈合。尽管单因素分析未能揭示任何特定风险因素对预后的显著影响,但缺损体积有统计学意义的趋势。进一步分析确实表明,较小的缺损体积(<8 cm)骨不连风险较低。
在我们大约一半的研究人群中,在节段性骨缺损病例中使用RIA技术采集自体骨移植导致骨愈合的成功结果。缺损大小似乎是影响预后的关键问题。尽管我们的结果不如先前发表的那样有前景,但RIA技术在节段性骨缺损的治疗算法中占有一席之地。