Gwee M C, Cheah L S
Life Sci. 1986 Aug 4;39(5):383-8. doi: 10.1016/0024-3205(86)90516-3.
Cimetidine and ranitidine are specific and potent H2-receptor antagonists widely used in the effective therapy of peptic ulcer disease. The drugs also possess other pharmacological properties unrelated to H2-receptor antagonism. More recently large experimental doses of cimetidine or ranitidine were found to have anticholinesterase, ganglion blocking and neuromuscular blocking activities. Actions of the drugs at such cholinergic sites may account for some of their clinically documented adverse effects. The toxicological implications of these findings including the potential for drug interactions to occur, especially during some anesthetic procedures, are discussed.
西咪替丁和雷尼替丁是特异性强效H2受体拮抗剂，广泛用于消化性溃疡疾病的有效治疗。这些药物还具有与H2受体拮抗作用无关的其他药理特性。最近发现，大剂量的西咪替丁或雷尼替丁具有抗胆碱酯酶、神经节阻断和神经肌肉阻断活性。药物在这些胆碱能部位的作用可能是其一些临床记录的不良反应的原因。本文讨论了这些发现的毒理学意义，包括药物相互作用的可能性，尤其是在一些麻醉过程中。
