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基于计算流体动力学方法的双吸式注射悬浮血泵的设计与血液相容性分析

Design and Hemocompatibility Analysis of a Double-Suction Injection Suspension Blood Pump Using Computational Fluid Dynamics Methods.

作者信息

Wu Yue, Zhu Liangfan, Luo Yun

机构信息

Institute of Biomedical Manufacturing and Life Quality Engineering, School of Mechanical Engineering Shanghai Jiao Tong University, Shanghai, China.

出版信息

Artif Organs. 2017 Nov;41(11):979-987. doi: 10.1111/aor.12888. Epub 2017 Jul 26.

Abstract

The blood pump has become a possible solution to heart diseases. For the prevention of device failure and hemocompatibility problems, a rotary pump with suspended bearing is a preferred solution. In our previous work, a novel injection suspension method has been introduced to levitate the rotor. The suspension method is totally passive. This study aims to apply this suspension method to a double-suction pump, and the property of the pump was investigated using computational fluid dynamics (CFD) methods. The flow field of the pump is simulated based on the SST k-ω turbulent model. The characteristic curves of the pump were calculated. At the nominal working point of 5 L/min, 100 mm Hg, the suspension force acting on the rotor was detected, which could reach 0.46 N with a gap of 150 µm. We compared the pump with a previously developed single-suction injection pump to evaluate the blood compatibility of the double-suction design. The average scalar shear stress values were 3.13 Pa for the double-suction pump and 7.10 Pa for the single-suction pump. Larger volumes in the single-suction pump were exposed to shear stresses higher than 10 Pa. Thresholds for the von Willebrand factor cleavage, platelet activation, and hemolysis were defined to be 9 Pa, 50 Pa, and 150 Pa, respectively. The volume fractions for the double-suction pump are lower for all thresholds. The normalized index of hemolysis (NIH) values for the two pumps were calculated to be 0.008 g/100 L and 0.016 g/100 L. Results proved that the double-suction pump has a better hemocompatibility compared with the single-suction pump.

摘要

血泵已成为治疗心脏病的一种可能解决方案。为防止设备故障和血液相容性问题,带有悬浮轴承的旋转泵是首选解决方案。在我们之前的工作中,引入了一种新颖的注射悬浮方法来悬浮转子。该悬浮方法完全是被动的。本研究旨在将这种悬浮方法应用于双吸泵,并使用计算流体动力学(CFD)方法研究该泵的性能。基于SST k-ω湍流模型对泵的流场进行了模拟。计算了泵的特性曲线。在5 L/min、100 mmHg的额定工作点,检测到作用在转子上的悬浮力,间隙为150 µm时该力可达0.46 N。我们将该泵与之前开发的单吸注射泵进行了比较,以评估双吸设计的血液相容性。双吸泵的平均标量剪应力值为3.13 Pa,单吸泵为7.10 Pa。单吸泵中更大的体积暴露于高于10 Pa的剪应力下。血管性血友病因子裂解、血小板活化和溶血的阈值分别定义为9 Pa、50 Pa和150 Pa。对于所有阈值,双吸泵的体积分数都更低。计算得出两台泵的归一化溶血指数(NIH)值分别为0.008 g/100 L和0.016 g/100 L。结果证明,与单吸泵相比,双吸泵具有更好的血液相容性。

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