Applied Research Laboratory and Department of Mechanical and Nuclear Engineering, Pennsylvania State University, University Park, PA, USA.
Artif Organs. 2011 May;35(5):522-33. doi: 10.1111/j.1525-1594.2010.01087.x. Epub 2010 Sep 24.
This article summarizes the use of computational fluid dynamics (CFD) to design a novel suspended Tesla left ventricular assist device. Several design variants were analyzed to study the parameters affecting device performance. CFD was performed at pump speeds of 6500, 6750, and 7000 rpm and at flow rates varying from 3 to 7 liters per minute (LPM). The CFD showed that shortening the plates nearest the pump inlet reduced the separations formed beneath the upper plate leading edges and provided a more uniform flow distribution through the rotor gaps, both of which positively affected the device hydrodynamic performance. The final pump design was found to produce a head rise of 77 mm Hg with a hydraulic efficiency of 16% at the design conditions of 6 LPM through flow and a 6750 rpm rotation rate. To assess the device hemodynamics the strain rate fields were evaluated. The wall shear stresses demonstrated that the pump wall shear stresses were likely adequate to inhibit thrombus deposition. Finally, an integrated field hemolysis model was applied to the CFD results to assess the effects of design variation and operating conditions on the device hemolytic performance.
本文总结了使用计算流体动力学（CFD）设计新型悬浮式特斯拉左心室辅助装置。分析了几种设计变体，以研究影响设备性能的参数。在泵速为 6500、6750 和 7000 rpm 以及流量为 3 至 7 升/分钟（LPM）的情况下进行了 CFD。CFD 表明，缩短靠近泵入口的板可以减少在上板前缘下方形成的分离，并通过转子间隙提供更均匀的流量分布，这两者都对设备的水动力性能产生了积极影响。最终的泵设计在 6 LPM 通过流量和 6750 rpm 转速的设计条件下，产生了 77 mmHg 的扬程提升和 16%的水力效率。为了评估装置的血液动力学，评估了应变率场。壁面切应力表明，泵壁面切应力可能足以抑制血栓形成。最后，将集成的场溶血模型应用于 CFD 结果，以评估设计变化和操作条件对设备溶血性能的影响。
