Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.
Department of Dermatology and Allergology, University Medical Center, Utrecht, The Netherlands.
Neurogastroenterol Motil. 2018 Jan;30(1). doi: 10.1111/nmo.13165. Epub 2017 Jul 26.
The incidence of eosinophilic esophagitis (EoE) has increased rapidly. Most epidemiologic data were gathered in single-center studies over a short timeframe, possibly explaining the heterogeneous incidences.
The aim of this study was to retrospectively estimate the Dutch nationwide incidence of EoE over the last 20 years.
The Dutch pathology registry (PALGA) was queried to identify pathology reports describing esophageal eosinophilia from 1996 to 2016. Cases were eligible if EoE was confirmed by the pathologist. Using the annual Dutch population data, the incidence of EoE was calculated.
The search yielded 11 288 reports of which 5080 described esophageal eosinophilia. Eosinophilic esophagitis was diagnosed in 2161 patients, 1574 (73%) males and 365 (17%) children. The incidence increased from 0.01 (95% CI 0-0.02) in 1996 to 2.07 (95% CI 2.05-2.23) per 100 000 inhabitants in 2015. The incidence was higher in males than in females, 3.02 (95% CI 2.66-3.41) vs 1.14 (95% CI 0.93-1.38), odds ratio (OR) 2.66 (95% CI 2.10-3.36) and higher in adults than in children, 2.23 (95% CI 1.99-2.49) vs 1.46 (95% CI 1.09-1.91), OR 1.78 (95% CI 1.32-2.40). Incidence of EoE increased more than 200-fold, whereas endoscopy rates only tripled, from 30 in 1996 to 105 per 100 000 inhabitants in 2015. We observed no seasonal variation.
In the last decades, the Dutch EoE incidence has increased tremendously and still continues to rise. This expansion is only partially driven by increased endoscopy rates.
嗜酸性食管炎（EoE）的发病率迅速上升。大多数流行病学数据是在短时间内通过单中心研究收集的，这可能解释了发病率的异质性。
本研究旨在回顾性估计过去 20 年来荷兰全国 EoE 的发病率。
查询荷兰病理学登记处（PALGA），以确定 1996 年至 2016 年描述食管嗜酸性粒细胞增多的病理学报告。如果病理学家确认存在 EoE，则病例符合纳入标准。使用年度荷兰人口数据计算 EoE 的发病率。
搜索共获得 11288 份报告，其中 5080 份描述了食管嗜酸性粒细胞增多。在 2161 例患者中诊断出嗜酸性食管炎，其中 1574 例（73%）为男性，365 例（17%）为儿童。发病率从 1996 年的 0.01（95%CI 0-0.02）增加到 2015 年的 2.07（95%CI 2.05-2.23）/100000 人。男性的发病率高于女性，分别为 3.02（95%CI 2.66-3.41）和 1.14（95%CI 0.93-1.38），比值比（OR）为 2.66（95%CI 2.10-3.36）；成年人的发病率高于儿童，分别为 2.23（95%CI 1.99-2.49）和 1.46（95%CI 1.09-1.91），OR 为 1.78（95%CI 1.32-2.40）。EoE 的发病率增加了 200 多倍，而内镜检查率仅增加了两倍，从 1996 年的 30 次/100000 人增加到 2015 年的 105 次/100000 人。我们未观察到季节性变化。
在过去几十年中，荷兰 EoE 的发病率急剧上升，且仍在继续上升。这种扩张在一定程度上是由内镜检查率的增加所驱动的。
