Mulvihill S, Pappas T N, Passaro E, Debas H T
Surgery. 1986 Sep;100(3):467-76.
Somatostatin is a naturally occurring peptide with a wide spectrum of biologic actions, most of which are inhibitory in nature. It has wide distribution, and within the gastrointestinal tract is is found in the pancreas, the stomach, intestinal mucosa, and myenteric neurons. It appears to function as a classic circulating hormone, as well as both a paracrine or locally acting agent and a neurocrine agent. Because of its inhibitory actions on gut endocrine, secretory, and motor functions, it has potential applicability in the treatment of a variety of disorders of interest to the surgeon. Indeed, it has been used successfully in the management of upper gastrointestinal hemorrhage, secretory diarrhea, short bowel syndrome, pancreatitis, gastrointestinal fistulas, and peptide-secreting tumors of the gut (apudomas). This review discusses physiology, pathophysiology, and therapeutic applications of somatostatin that may be important in surgical practice.
生长抑素是一种天然存在的肽，具有广泛的生物学作用，其中大多数本质上是抑制性的。它分布广泛，在胃肠道内，可在胰腺、胃、肠黏膜和肌间神经中发现。它似乎既作为一种经典的循环激素发挥作用，又作为旁分泌或局部作用因子以及神经分泌因子发挥作用。由于其对肠道内分泌、分泌和运动功能具有抑制作用，它在治疗外科医生感兴趣的多种疾病方面具有潜在的适用性。事实上，它已成功用于治疗上消化道出血、分泌性腹泻、短肠综合征、胰腺炎、胃肠瘘和肠道肽分泌肿瘤（APUD瘤）。本综述讨论了生长抑素在外科实践中可能重要的生理学、病理生理学和治疗应用。
