Mulvihill S J, Pappas T N, Fonkalsrud E W, Debas H T
Department of Surgery, University of California, San Francisco 94143-0104.
Ann Surg. 1988 Feb;207(2):169-73. doi: 10.1097/00000658-198802000-00009.
The effect of somatostatin (SS-14) was tested in an anesthetized rabbit model of closed-loop ileal obstruction. Experimental groups included (1) immediate treatment (N = 6) receiving SS-14 2,000 pmol X kg-1 X h-1 intravenously (I.V.) beginning at the time of ileal obstruction, (2) delayed treatment (N = 5) receiving SS-14 beginning 6 hours following ileal obstruction, and (3) control (N = 6) receiving only hydration. After 24 hours, all rabbits were killed. Significantly decreased intestinal luminal volume and sodium and potassium output was observed with both immediate and delayed SS-14 treatment when compared to control. Additionally, the gross and microscopic pathologic features of intestinal distension, inflammation, and necrosis seen in control rabbits were absent in rabbits treated with SS-14. The known broad spectrum of physiologic activity of SS-14 on the gastrointestinal tract appeared beneficial in this rabbit model of intestinal obstruction.
在麻醉的兔闭环回肠梗阻模型中测试了生长抑素（SS - 14）的作用。实验组包括：（1）立即治疗组（N = 6），在回肠梗阻发生时开始静脉注射（I.V.）2000 pmol·kg⁻¹·h⁻¹的SS - 14；（2）延迟治疗组（N = 5），在回肠梗阻6小时后开始接受SS - 14治疗；（3）对照组（N = 6），仅接受补液。24小时后，处死所有兔子。与对照组相比，立即和延迟给予SS - 14治疗均观察到肠腔容积以及钠和钾排出量显著降低。此外，接受SS - 14治疗的兔子未出现对照组兔子中所见的肠扩张、炎症和坏死的大体及微观病理特征。SS - 14对胃肠道已知的广泛生理活性在该兔肠梗阻模型中似乎具有益处。
