Lotti Claudia Beatriz de Campos, Oliveira Acary Souza Bulle, Bichuetti Denis Bernardi, Castro Isac de, Oliveira Enedina Maria Lobato
Universidade Federal de São Paulo, Departamento de Neurologia, São Paulo SP, Brasil.
Universidade de São Paulo, Faculdade de Medicina, Disciplina de Nefrologia, São Paulo SP, Brasil.
Arq Neuropsiquiatr. 2017 Jul;75(7):451-456. doi: 10.1590/0004-282X20170070.
Late onset multiple sclerosis (LOMS) is when the first symptom starts after 50 years of age, representing 4.5% of multiple sclerosis (MS) patients. This study describes the clinical characteristics of patients with LOMS followed at a specialized MS center in São Paulo. Data was obtained from medical records of 742 patients with MS. The LOMS frequency was 4.18%, median age at onset was 54 years and the predominant disease course was primary progressive (64.3%). The patients reached the disability landmarks of EDSS grades 3.0, 6.0 and 7.0 in the following proportion and time: EDSS 3.0: 77.42% of patients in 3.7 years; EDSS 6.0: 58.06% in 5.1 years and EDSS 7.0: 32.26% in 5.7 years. The comparative analysis with a matched control group of patients with early onset MS showed that late onset, associated with a progressive course, were predictors of reaching EDSS 3.0 and 6.0 in a shorter time.
迟发性多发性硬化症（LOMS）是指首发症状出现在50岁之后的多发性硬化症（MS），占MS患者的4.5%。本研究描述了在圣保罗一家专业MS中心随访的LOMS患者的临床特征。数据来自742例MS患者的病历。LOMS的发生率为4.18%，发病年龄中位数为54岁，主要病程为原发进展型（64.3%）。患者达到扩展残疾状态量表（EDSS）3.0、6.0和7.0级残疾标志的比例及时间如下：EDSS 3.0：77.42%的患者在3.7年内达到；EDSS 6.0：58.06%的患者在5.1年内达到；EDSS 7.0：32.26%的患者在5.7年内达到。与早发性MS患者的匹配对照组进行的对比分析表明，迟发性且伴有进展性病程是在更短时间内达到EDSS 3.0和6.0的预测因素。
