Paju Susanna, Oittinen Juha, Haapala Henna, Asikainen Sirkka, Paavonen Jorma, Pussinen Pirkko J
Oral and Maxillofacial Diseases, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Faculty of Dentistry, Health Sciences Center, Kuwait University, Safat, Kuwait.
J Oral Microbiol. 2017 Jun 12;9(1):1330644. doi: 10.1080/20002297.2017.1330644. eCollection 2017.
In this observational and prospective study, we investigated if microbiological and serological markers of periodontitis associated with conception in 256 non-pregnant women ( = 29.2 years; range 19-42 years). Clinical oral and gynecological examinations were performed, major periodontal pathogens in the saliva were detected, and serum and saliva antibodies against major periodontal pathogens were analyzed. The follow-up period for becoming pregnant was 12 months. was significantly ( = 0.032) more frequently detected in the saliva among those who did not become pregnant (8.3%) than among those who became pregnant (2.1%). The median levels of salivary P. gingivalis immunoglobulin A (IgA; p = 0.006) and IgG ( = 0.007) antibodies were higher among those who did not become pregnant compared to those who became pregnant. Hazard ratios (HR) for not becoming pregnant were HR = 3.75 (95% confidence interval [CI] 1.01-13.9; p = 0.048) if the subject was polymerase chain reaction-positive for with high salivary antibodies against it, and HR = 1.62 (95% CI 1.03-2.54; = 0.035) if she had high levels of serum P. gingivalis IgA and signs of periodontal infection. associated with no success in getting pregnant.
在这项观察性前瞻性研究中，我们调查了256名未怀孕女性（平均年龄=29.2岁；范围19 - 42岁）中与受孕相关的牙周炎微生物学和血清学标志物。进行了临床口腔和妇科检查，检测了唾液中的主要牙周病原体，并分析了针对主要牙周病原体的血清和唾液抗体。怀孕的随访期为12个月。未怀孕者唾液中（8.3%）比怀孕者唾液中（2.1%）更频繁地检测到[具体病原体名称未给出]（p = 0.032）。未怀孕者唾液中牙龈卟啉单胞菌免疫球蛋白A（IgA；p = 0.006）和IgG（p = 0.007）抗体的中位数水平高于怀孕者。如果受试者针对[具体病原体名称未给出]的聚合酶链反应呈阳性且唾液抗体水平高，则未怀孕的风险比（HR）为HR = 3.75（95%置信区间[CI]1.01 - 13.9；p = 0.048）；如果她血清牙龈卟啉单胞菌IgA水平高且有牙周感染迹象，则HR = 1.62（95%CI 1.03 - 2.54；p = 0.035）。[具体病原体名称未给出]与受孕不成功相关。
