Laboratory of Experimental Medicine, Centre of New Technologies, University of Warsaw, Banacha 2c, 02-097, Warsaw, Poland.
Department of Immunology, Center of Biostructure Research, Medical University of Warsaw, Warsaw, Poland.
Arch Immunol Ther Exp (Warsz). 2018 Apr;66(2):125-132. doi: 10.1007/s00005-017-0481-7. Epub 2017 Jul 26.
Stimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment. It has been shown that activation of the STING-dependent pathway in cancer cells can result in tumor infiltration with immune cells and modulation of the anticancer immune response. Understanding the function of STING pathway in cancer cells might provide important insights into the development of effective therapeutic strategies. This review focuses on the role of STING pathway in cancer cells, the largely unknown topic that has recently emerged to be important in the context of STING-mediated antitumor responses.
干扰素基因刺激物 (STING) 是一种衔接蛋白，在细胞溶质核酸配体对 I 型干扰素的激活中发挥重要作用。最近的证据表明，STING 途径参与了抗肿瘤免疫反应的诱导。因此，STING 激动剂目前正在被广泛开发为一类新的癌症治疗药物。然而，对于激活的 STING 介导的信号在癌细胞中对抗肿瘤治疗效果的影响知之甚少。已经表明，癌细胞中 STING 依赖性途径的激活可导致肿瘤浸润免疫细胞和抗肿瘤免疫反应的调节。了解 STING 途径在癌细胞中的功能可能为开发有效的治疗策略提供重要的见解。本综述重点介绍 STING 途径在癌细胞中的作用，这是一个最近出现的重要课题，在 STING 介导的抗肿瘤反应中具有重要意义。
