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本文引用的文献

1
The relative activities of some tryptamine analogues on the isolated rat stomach strip preparation.一些色胺类似物对离体大鼠胃条标本的相对活性。
Br J Pharmacol Chemother. 1959 Mar;14(1):87-98. doi: 10.1111/j.1476-5381.1959.tb00933.x.
2
Alpha-adrenoceptors, 5-hydroxytryptamine receptors and the action of dihydroergotamine in human venous preparations obtained during saphenectomy procedures for varicose veins.α-肾上腺素能受体、5-羟色胺受体以及双氢麦角胺在大隐静脉切除术治疗静脉曲张过程中获取的人体静脉制剂中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 1984 Oct;327(4):299-303. doi: 10.1007/BF00506240.
3
Pharmacological studies on frozen stored canine saphenous veins and basilar arteries.冷冻保存的犬隐静脉和基底动脉的药理学研究。
Naunyn Schmiedebergs Arch Pharmacol. 1986 Jan;332(1):74-8. doi: 10.1007/BF00633201.

在-190℃储存后人体静脉的功能研究。

Functional studies on human veins after storage at--190 degrees C.

作者信息

Müller-Schweinitzer E, Tapparelli C, Victorzon M

出版信息

Br J Pharmacol. 1986 Jul;88(3):685-7. doi: 10.1111/j.1476-5381.1986.tb10251.x.

DOI:10.1111/j.1476-5381.1986.tb10251.x
PMID:2874858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916970/
Abstract

Human saphenous veins were immersed in foetal calf serum containing 1.8 M dimethylsulphoxide, slowly frozen to -70 degrees C and stored in liquid nitrogen (-190 degrees C). Comparative in vitro studies on helical strips from unfrozen and frozen and thawed veins revealed that after thawing of frozen stored veins the contractile force development was unchanged, and the evidence suggested that the monoamine oxidase activity was unimpaired. There was a good correlation between the pD2 values of various 5-hydroxytryptamine receptor agonists and the blocking activities of various antagonists tested against 5-hydroxytryptamine (5-HT) and noradrenaline on unfrozen and frozen and thawed veins. It is suggested that cryopreservation is a useful technique for storing human veins for pharmacological studies.

摘要

将人隐静脉浸入含有1.8M二甲基亚砜的胎牛血清中，缓慢冷冻至-70℃，并储存在液氮（-190℃）中。对未冷冻、冷冻和解冻静脉的螺旋条进行的体外比较研究表明，冷冻保存的静脉解冻后收缩力的发展没有变化，且有证据表明单胺氧化酶活性未受损。各种5-羟色胺受体激动剂的pD2值与各种拮抗剂对未冷冻、冷冻和解冻静脉上5-羟色胺（5-HT）和去甲肾上腺素的阻断活性之间存在良好的相关性。有人提出，冷冻保存是一种用于储存人静脉以进行药理学研究的有用技术。