Myśliwiec H, Kiluk P, Myśliwiec P, Żelazowska-Rutkowska B, Baran A, Flisiak I
Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
First Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
Clin Exp Dermatol. 2017 Oct;42(7):786-790. doi: 10.1111/ced.13188. Epub 2017 Jul 27.
Psoriasis is characterized by keratinocyte resistance to apoptosis. We recently demonstrated an increase in serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients after topical treatment for psoriasis. We decided to verify whether narrowband ultraviolet B (NB-UVB) has a similar effect. Serum concentration of TWEAK was estimated in patients with exacerbated plaque psoriasis treated with NB-UVB. Baseline TWEAK levels were similar in patients with psoriasis and healthy controls, and Psoriasis Area and Severity Index (PASI) correlated inversely with TWEAK levels. Treatment with NB-UVB caused a significant reduction in PASI and concurrent increase in serum TWEAK. This finding may be due to increased expression of TWEAK receptor in psoriatic skin, which has been reported previously, with consequent binding of excess soluble TWEAK during treatment and subsequent release after treatment. Severity of plaque psoriasis and its improvement after NB-UVB treatment may be associated with TWEAK concentrations. The importance of our findings remains to be established.
银屑病的特征是角质形成细胞对细胞凋亡具有抗性。我们最近发现，银屑病患者经局部治疗后血清肿瘤坏死因子样凋亡弱诱导剂（TWEAK）水平升高。我们决定验证窄谱中波紫外线（NB-UVB）是否具有类似作用。对接受NB-UVB治疗的斑块状银屑病加重患者的血清TWEAK浓度进行了评估。银屑病患者和健康对照者的基线TWEAK水平相似，银屑病面积和严重程度指数（PASI）与TWEAK水平呈负相关。NB-UVB治疗导致PASI显著降低，同时血清TWEAK升高。这一发现可能是由于银屑病皮肤中TWEAK受体表达增加，此前已有报道，治疗期间过量可溶性TWEAK与之结合，治疗后随后释放。斑块状银屑病的严重程度及其在NB-UVB治疗后的改善可能与TWEAK浓度有关。我们研究结果的重要性仍有待确定。
