Myśliwiec Hanna, Myśliwiec Piotr, Baran Anna, Flisiak Iwona
Department of Dermatology and Venereology, Medical University of Bialystok, Bialystok, Poland.
I Department of General and Endocrinological Surgery, Medical University of Bialystok, Bialystok, Poland.
Adv Med Sci. 2016 Sep;61(2):207-211. doi: 10.1016/j.advms.2016.01.001. Epub 2016 Jan 21.
TNF-like weak inducer of apoptosis (TWEAK) mediates not only apoptosis, but also inflammation, cell growth and angiogenesis. The role of TWEAK in psoriasis remains unknown. The aim of the study was to assess serum levels of TWEAK in psoriatic patients before and after topical treatment with dithranol in relation to the clinical activity of the disease.
Serum samples were collected from 40 patients with plaque type psoriasis before and after topical treatment with dithranol. The concentrations of serum TWEAK were measured by ELISA and next compared with 16 healthy controls. The data were analyzed with respect to Psoriasis Area and Severity Index (PASI).
Baseline serum TWEAK concentrations of psoriatic patients (685±166pg/ml) were significantly greater compared to healthy controls (565±110pg/ml). Topical treatment resulted in further increase in serum TWEAK (749±179pg/ml; p<0.01). In case of patients with initial serum TWEAK concentrations above the median, PASI after topical treatment was lower compared to the individuals with initial TWEAK below the median.
According to the study, serum Tweak was increased in psoriasis patients compared with controls. Moreover, dithranol topical treatment caused further increase in serum TWEAK. Also, a higher effectiveness of topical treatment was observed in case of patients with higher initial TWEAK concentrations. The results suggest a potential role of TWEAK in psoriasis therapy.
肿瘤坏死因子样凋亡微弱诱导剂（TWEAK）不仅介导细胞凋亡，还参与炎症、细胞生长和血管生成过程。TWEAK在银屑病中的作用尚不清楚。本研究旨在评估用蒽林局部治疗前后银屑病患者血清中TWEAK水平，并探讨其与疾病临床活动度的关系。
收集40例斑块型银屑病患者在蒽林局部治疗前后的血清样本。采用酶联免疫吸附测定法（ELISA）检测血清TWEAK浓度，并与16名健康对照者进行比较。数据根据银屑病面积和严重程度指数（PASI）进行分析。
银屑病患者的基线血清TWEAK浓度（685±166pg/ml）显著高于健康对照者（565±110pg/ml）。局部治疗导致血清TWEAK进一步升高（749±179pg/ml；p<0.01）。初始血清TWEAK浓度高于中位数的患者，局部治疗后的PASI低于初始TWEAK浓度低于中位数的患者。
根据本研究，银屑病患者血清中的Tweak水平高于对照组。此外，蒽林局部治疗导致血清TWEAK进一步升高。而且，初始TWEAK浓度较高的患者局部治疗效果更佳。结果提示TWEAK在银屑病治疗中可能发挥作用。
