Cedars-Sinai Medical Center, Regenerative Medicine Institute, Los Angeles, California, USA.
David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Stem Cells. 2017 Oct;35(10):2105-2114. doi: 10.1002/stem.2667. Epub 2017 Jul 26.
Corneal wound healing is a complex process that occurs in response to various injuries and commonly used refractive surgery. It is a significant clinical problem, which may lead to serious complications due to either incomplete (epithelial) or excessive (stromal) healing. Epithelial stem cells clearly play a role in this process, whereas the contribution of stromal and endothelial progenitors is less well studied. The available evidence on stem cell participation in corneal wound healing is reviewed, together with the data on the use of corneal and non-corneal stem cells to facilitate this process in diseased or postsurgical conditions. Important aspects of corneal stem cell generation from alternative cell sources, including pluripotent stem cells, for possible transplantation upon corneal injuries or in disease conditions are also presented. Stem Cells 2017;35:2105-2114.
角膜创伤愈合是一个复杂的过程，发生于各种创伤和常见的屈光手术之后。它是一个重要的临床问题，可能会因愈合不完全（上皮）或过度（基质）而导致严重的并发症。上皮干细胞显然在这个过程中起着重要的作用，而基质和内皮祖细胞的贡献则研究得较少。本文回顾了有关干细胞参与角膜创伤愈合的研究，并介绍了使用角膜和非角膜干细胞来促进病变或手术后情况下的愈合过程的数据。还介绍了从替代细胞来源（包括多能干细胞）产生角膜干细胞，以在角膜损伤或疾病状态下进行移植的重要方面。
