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在急性猴免疫缺陷病毒/人免疫缺陷病毒（SHIV）感染期间，CD4+细胞浸润至皮下脂肪组织并不表明存在有病毒复制能力的感染细胞。

CD4+ Cell infiltration into subcutaneous adipose tissue is not indicative of productively infected cells during acute SHIV infection.

作者信息

Hsu Denise C, Wegner Matthew D, Sunyakumthorn Piyanate, Silsorn Decha, Tayamun Sujitra, Inthawong Dutsadee, Kuncharin Yanin, Im-Erbsin Rawiwan, Ege Christine, O'Connell Robert J, Michael Nelson L, Ndhlovu Lishomwa C, Vasan Sandhya

机构信息

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

出版信息

J Med Primatol. 2017 Aug;46(4):154-157. doi: 10.1111/jmp.12298.

DOI:10.1111/jmp.12298
PMID:28748665
Abstract

Limited longitudinal data exist on the effect of HIV on adipose tissue (AT). We found an increase in CD4+ cells and detectable SHIV-RNA in AT during acute SHIV infection. SHIV-RNA+ cells were rare, suggesting that AT is unlikely to be a major source of productively infected cells in SHIV infection.

摘要

关于人类免疫缺陷病毒（HIV）对脂肪组织（AT）影响的纵向数据有限。我们发现在急性猿猴-人免疫缺陷病毒（SHIV）感染期间，脂肪组织中的CD4 +细胞增加且可检测到SHIV-RNA。SHIV-RNA阳性细胞很少见，这表明脂肪组织不太可能是SHIV感染中产生有效感染细胞的主要来源。

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