勃起功能障碍、合并症与帕金森病之间的关系：基于人群的纵向研究证据
Relationship between Erectile Dysfunction, Comorbidity, and Parkinson's Disease: Evidence from a Population-Based Longitudinal Study.
作者信息
Yang Yuwan, Liu Hsinho, Lin Tienhuang, Kuo Yuhung, Hsieh Tengfu
机构信息
Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
School of Medicine, China Medical University, Taichung, Taiwan.
出版信息
J Clin Neurol. 2017 Jul;13(3):250-258. doi: 10.3988/jcn.2017.13.3.250.
BACKGROUND AND PURPOSE
To determine the risk of Parkinson's disease (PD) in relation to erectile dysfunction (ED) based on the National Health Insurance Research Database in Taiwan.
METHODS
We identified 3,153 patients who were newly diagnosed with ED between January 1, 2004 and December 31, 2010. A total of 12,612 randomly selected people without ED served as healthy controls. All of the study subjects were followed-up from the index date to the date of PD diagnosis, withdrawal from the National Health Insurance program, or the end of 2012 whichever occurred first.
RESULTS
The incidence density rate of PD was 1.52-fold higher in the ED cohort than the non-ED cohort (3.44 vs. 1.64 per 1,000 person-years), with an adjusted hazard ratio (HR) of 1.52 [95% confidence interval (CI)=1.09-2.12]. The combined effects on patients with ED and diabetes as well as hypertension showed a significant combined association with the PD risk compared with patients without ED, counterpart comorbidities, or medication use. The adjusted HR of PD for ED was higher for diabetes (2.82, 95% CI=1.42-5.63) and hypertension (2.19, 95% CI = 1.35-3.55).
CONCLUSIONS
ED leads to an increased risk of PD. ED patients with diabetes or hypertension have an elevated risk of PD.
背景与目的
基于台湾国民健康保险研究数据库，确定勃起功能障碍（ED）与帕金森病（PD）的患病风险关系。
方法
我们确定了2004年1月1日至2010年12月31日期间新诊断为ED的3153例患者。总共随机选取12612例无ED的人作为健康对照。所有研究对象从索引日期开始随访，直至PD诊断日期、退出国民健康保险计划或2012年底（以先发生者为准）。
结果
ED队列中PD的发病密度率比非ED队列高1.52倍（每1000人年分别为3.44和1.64），调整后的风险比（HR）为1.52 [95%置信区间（CI）=1.09 - 2.12]。与无ED、相应合并症或未使用药物的患者相比，ED合并糖尿病以及高血压患者与PD风险存在显著的联合关联。糖尿病患者中ED导致PD的调整后HR更高（2.82，95% CI = 1.42 - 5.63），高血压患者中则为（2.19，95% CI = 1.35 - 3.55）。
结论
ED会导致PD风险增加。患有糖尿病或高血压的ED患者患PD的风险更高。
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