Jiménez-Huete Adolfo, Del Barrio Antonio, Riva Elena, Campo Pablo, Toledano Rafael, Franch Oriol
Department of Neurology, General Neurology Unit, Hospital Ruber Internacional, Madrid, Spain.
Department of Basic Psychology, Autonoma University of Madrid, Madrid, Spain.
J Clin Neurol. 2017 Jul;13(3):259-264. doi: 10.3988/jcn.2017.13.3.259.
We aimed to determine the correlation between subjective evaluations of mood and cognitive functions by patients and informants, and the findings of a battery of neuropsychological tests.
We analyzed 74 subjects recruited from a general neurology clinic, comprising 37 patients with cognitive complaints and 37 informants (either relatives or caregivers in close contact with the patients). Four ordinal scales concerning recent memory, verbal expression, initiative, and mood were correlated with the findings of a series of neuropsychological tests and questionnaires using the tau b coefficient.
The scores for the patients on the scales were most strongly correlated with scores on the 15-item Geriatric Depression Scale (GDS-15), while the scores for the informants were most strongly correlated with scores on GDS-15, the Informant Questionnaire on Cognitive Decline, and the Functional Activities Questionnaire (FAQ). The most significant correlation was between the initiative scale from informants and FAQ (tau b=-0.591, p<0.001), and it was the only one that remained significant after correcting for multiple testing (p Holm=0.013).
Cognitive complaints from patients mainly reflect their mood, whilst informant reports mainly reflect both the functional ability and mood of the patients.
我们旨在确定患者及提供信息者对情绪和认知功能的主观评估与一系列神经心理学测试结果之间的相关性。
我们分析了从普通神经科门诊招募的74名受试者，其中包括37名有认知主诉的患者和37名提供信息者（与患者密切接触的亲属或照料者）。使用tau b系数，将关于近期记忆、言语表达、主动性和情绪的四个序数量表与一系列神经心理学测试和问卷的结果进行相关性分析。
患者在这些量表上的得分与15项老年抑郁量表（GDS - 15）的得分相关性最强，而提供信息者的得分与GDS - 15、认知能力下降信息问卷和功能活动问卷（FAQ）的得分相关性最强。提供信息者的主动性量表与FAQ之间的相关性最为显著（tau b = - 0.591，p < 0.001），并且在进行多重检验校正后，它是唯一仍然显著的相关性（p Holm = 0.013）。
患者的认知主诉主要反映其情绪，而提供信息者的报告主要反映患者的功能能力和情绪。
