Niu Hui-Xia, Wang Rui-Hao, Xu Hong-Liang, Song Bo, Yang Jing, Shi Chang-He, Li Yu-Sheng, Zhang Bing-Qian, Wang Shao-Ping, Yong Quan, Wang Yuan-Yuan, Xu Yu-Ming
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Chin Med J (Engl). 2017 Aug 5;130(15):1773-1778. doi: 10.4103/0366-6999.211550.
The 9-hole peg test (9-HPT) and 10-meter walk test (10-MWT) are commonly used to test finger motor function and walking ability. The aim of this present study was to investigate the efficacy of these tests for evaluating functional loss in Chinese Charcot-Marie-Tooth (CMT) disease.
Thirty-four Chinese CMT patients (CMT group) from August 2015 to December 2016 were evaluated with 9-HPT, 10-MWT, CMT disease examination score, overall neuropathy limitation scale (ONLS), functional disability score, and Berg Balance Scale (BBS). Thirty-five age- and gender-matched healthy controls (control group) were also included in the study. Student's nonpaired or paired t-test were performed to compare data between two independent or related groups, respectively. The Pearson test was used to examine the correlations between recorded parameters.
The mean 9-HPT completion time in the dominant hand of CMT patients was significantly slower than that in the healthy controls (29.60 ± 11.89 s vs. 19.58 ± 3.45 s; t = -4.728, P < 0.001). Women with CMT completed the 9-HPT significantly faster than men with CMT (dominant hand: 24.74 ± 7.93 s vs. 33.01 ± 13.14 s, t = 2.097, P = 0.044). The gait speed of the average self-selected velocity and the average fast-velocity assessed using 10-MWT for CMT patients were significantly slower than those in the control group (1.03 ± 0.18 m/s vs. 1.44 ± 0.17 m/s, t = 9.333, P < 0.001; 1.31 ± 0.30 m/s vs. 1.91 ± 0.25 m/s, t = 8.853, P < 0.001, respectively). There was no difference in gait speed between men and women. Both 9-HPT and 10-MWT were significantly correlated with the ONLS, functional disability score, and BBS (P < 0.05 for all).
The 9-HPT and 10-MWT might be useful for functional assessment in Chinese patients with CMT.
9孔插钉试验（9-HPT）和10米步行试验（10-MWT）常用于测试手指运动功能和步行能力。本研究的目的是探讨这些测试对评估中国遗传性运动感觉神经病（CMT）患者功能丧失的有效性。
选取2015年8月至2016年12月期间的34例中国CMT患者（CMT组），采用9-HPT、10-MWT、CMT疾病检查评分、总体神经病变限制量表（ONLS）、功能残疾评分和伯格平衡量表（BBS）进行评估。研究还纳入了35例年龄和性别匹配的健康对照者（对照组）。分别采用学生非配对或配对t检验比较两个独立或相关组的数据。采用Pearson检验分析记录参数之间的相关性。
CMT患者优势手的平均9-HPT完成时间显著慢于健康对照者（29.60±11.89秒对19.58±3.45秒；t=-4.728，P<0.001）。CMT女性患者完成9-HPT的速度明显快于CMT男性患者（优势手：24.74±7.93秒对33.01±13.14秒，t=2.097，P=0.044）。CMT患者使用10-MWT评估的平均自选速度和平均快速速度的步态速度显著慢于对照组（1.03±0.18米/秒对1.44±0.17米/秒，t=9.333，P<0.001；1.31±0.30米/秒对1.91±0.25米/秒，t=8.853，P<0.001）。男性和女性之间的步态速度没有差异。9-HPT和10-MWT均与ONLS、功能残疾评分和BBS显著相关（均P<0.05）。
9-HPT和10-MWT可能有助于对中国CMT患者进行功能评估。
