Aranguren Camilo, Vergara Camila, Rosselli Diego
Clinical Epidemiology and Biostatistics Department, Pontificia Universidad Javeriana; Medical School, Pontificia Universidad Javeriana, Bogota, Colombia.
Medical School, Pontificia Universidad Javeriana, Bogota, Colombia.
Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):709-715.
Several reports have discussed the neurotoxic effects of star fruit (Averrhoa carambola) in patients with chronic kidney disease (CKD). There is also some evidence highlighting the potentially harmful effects on patients with apparently normal renal function, who after consuming this fruit, developed acute renal injury. We performed a systematic review of the literature in the two main global databases (PubMed and Embase) as well as in Lilacs, for Latin American publications. We also included case reports, case series, or review articles which presented individual patient data. Animal or in vitro studies were excluded. We initially screened 259 references, of which 42 were selected for full-text review and 26 were finally selected for data extraction. A total of 123 patients from eight countries were documented: Brazil, with 47 cases, had the highest reported incidence, followed by Taiwan (36), Bangladesh (20), China and France (8 each), Sri Lanka (2), and Thailand and Colombia (1 each); 28 (22%) of the patients died. Despite the relatively low frequency of star fruit consumption, it has become a global issue. Patients with already diagnosed CKD are the obvious target for preventive measures, but persons with undiagnosed kidney conditions could also be at risk.
几份报告讨论了杨桃（阳桃）对慢性肾脏病（CKD）患者的神经毒性作用。也有一些证据表明，食用这种水果后出现急性肾损伤的肾功能看似正常的患者也可能受到有害影响。我们对两个主要全球数据库（PubMed和Embase）以及拉丁美洲出版物的Lilacs中的文献进行了系统综述。我们还纳入了呈现个体患者数据的病例报告、病例系列或综述文章。动物或体外研究被排除。我们最初筛选了259篇参考文献，其中42篇被选进行全文审查，最终26篇被选进行数据提取。记录了来自八个国家的123名患者：巴西报告的发病率最高，有47例，其次是台湾（36例）、孟加拉国（20例）、中国和法国（各8例）、斯里兰卡（2例）以及泰国和哥伦比亚（各1例）；28名（22%）患者死亡。尽管食用杨桃的频率相对较低，但它已成为一个全球性问题。已确诊CKD的患者显然是预防措施的目标人群，但未确诊肾脏疾病的人也可能面临风险。
