Vallianou Natalia, Giannopoulou Myrto, Trigkidis Kyriakos, Bei Elefteria, Margellou Evangelia, Apostolou Theofanis
Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece.
Department of Nephrology, Evangelismos General Hospital, Athens, Greece.
Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):906-908.
Carbamazepine intoxication manifests as altered mental status ranging from drowsiness to a coma and/or cardiac abnormalities such as sinus tachycardia, prolongation of the QRS interval, ventricular tachycardia, and hypotension. The patient may be agitated, but central nervous system (CNS) depression and presentation with coma is more common and could be lethal. Serious CNS toxicity often requires hemoperfusion and/or hemodialysis (HD). Herein, we present a case of a comatose patient, who was treated with a combination of hemoperfusion and HD in series. Our approach to treat the patient with a combination of hemoperfusion and HD was based on evidence from the literature supporting that the hemoperfusion and HD in series might provide the best clearance of carbamazepine.
卡马西平中毒表现为精神状态改变，从嗜睡到昏迷，和/或心脏异常，如窦性心动过速、QRS间期延长、室性心动过速和低血压。患者可能烦躁不安，但中枢神经系统（CNS）抑制和昏迷表现更为常见且可能致命。严重的CNS毒性通常需要血液灌流和/或血液透析（HD）。在此，我们报告一例昏迷患者，其接受了血液灌流和HD串联联合治疗。我们采用血液灌流和HD联合治疗该患者的方法是基于文献证据，支持血液灌流和HD串联可能提供卡马西平的最佳清除效果。
