Department of Anesthesiology, Medical Faculty, Yuzuncu Yil University, Turkey.
Am J Emerg Med. 2010 Feb;28(2):260.e1-2. doi: 10.1016/j.ajem.2009.06.013.
Carbamazepine (CBZ) is a commonly used antiepileptic agent. Common toxic effects include neurological abnormalities; ataxia, seizures, coma, cardiorespiratory problems; dysrhythmias; conduction disorders; respiratory depression; and eye abnormalities, such as nystagmus and ophthalmoplegia. Carbamazepine is highly protein bound. There is no antidote for the medication. Carbamazepine is not removed effectively through conventional hemodialysis. Supportive measures and charcoal hemoperfusion have been regarded as efficient treatment methods. We herein report a 17-year old girl to whom continuous venovenous hemodiafiltration lacking the albumin-enhance after suicidal overdose of CBZ was performed. We suggest continuous venovenous hemodiafiltration lacking the albumin-enhance as an alternative emergency treatment modality for cases who had ingested CBZ in toxic levels.
卡马西平（CBZ）是一种常用的抗癫痫药物。常见的毒性作用包括神经异常；共济失调、癫痫发作、昏迷、心肺问题；心律失常；传导障碍；呼吸抑制；以及眼球异常，如眼球震颤和眼肌麻痹。卡马西平高度结合蛋白。该药物没有解毒剂。常规血液透析不能有效地清除卡马西平。支持性措施和活性炭血液灌流被认为是有效的治疗方法。我们在此报告了一名 17 岁女孩，她因自杀过量服用卡马西平后接受了无白蛋白增强的连续静脉-静脉血液透析滤过治疗。我们建议对摄入毒性水平卡马西平的病例，使用无白蛋白增强的连续静脉-静脉血液透析滤过作为替代紧急治疗方式。
