Chandra Abhilash, Kaul Anupama, Aggarwal Vinita
Department of Nephrology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Nephrology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Saudi J Kidney Dis Transpl. 2017 Jul-Aug;28(4):937-941.
Paraproteins can cause a variable set of pathologic changes in the kidney. The introduction of novel anti-plasma cell agents capable of reversing renal failure have revolutionized the management of paraprotein-mediated kidney injury. Activation of the transcription factor nuclear factor kB (NF-kB) has been shown to be involved in the development of human glomerulonephritis (GN). Inhibitors of NF-kB may provide potential agents for treatment of immune complex GN. In this paper, we report a patient with IgA nephropathy and IgG kappa myeloma, who responded dramatically to chemotherapy targeted toward myeloma. Our findings support the idea that drugs modulating NF-kB may add another dimension to the management of IgA nephropathy.
副蛋白可在肾脏引起一系列不同的病理变化。能够逆转肾衰竭的新型抗浆细胞药物的出现彻底改变了副蛋白介导的肾损伤的治疗方法。转录因子核因子κB（NF-κB）的激活已被证明与人类肾小球肾炎（GN）的发展有关。NF-κB抑制剂可能为免疫复合物性GN的治疗提供潜在药物。在本文中，我们报告了一名患有IgA肾病和IgG κ型骨髓瘤的患者，该患者对针对骨髓瘤的化疗有显著反应。我们的研究结果支持这样一种观点，即调节NF-κB的药物可能为IgA肾病的治疗增添新的维度。
