Department of Anesthesia and Intensive Care Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Anesthesia and Intensive Care Medicine, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark.
Minerva Anestesiol. 2018 Feb;84(2):168-177. doi: 10.23736/S0375-9393.17.11718-9. Epub 2017 Jul 26.
Anterior cruciate ligament reconstruction (ACL-RC) is often associated with moderate to severe postoperative pain even with a multimodal analgesic regimen. We aimed to compare the analgesic efficacy of low volume saphenous-obturator block with placebo and femoral-obturator block in patients undergoing ACL-RC.
In a randomized controlled trial eighty-two patients undergoing ACL-RC with hamstring autograft were allocated to either low volume saphenous-obturator block, placebo block or femoral-obturator block. Ropivacaine 0.75% was used for active blocks and saline for placebo. Primary outcome was pain-scores at rest quantified as area-under-the-curve 0-6 hr postoperatively. Secondary outcomes were postoperative opioid consumption and pain localization in the knee.
No statistical difference existed between groups in area-under-the-curve 6 hr pain-scores. However, pain-scores were significantly lower in the two ropivacaine groups compared to placebo at emergence t=0 (P<0.018), at t=5 (P<0.042) and at t=6 hours (P<0.002) postoperatively. Furthermore, ropivacaine blocks exhibited significantly reduced total opioid consumption (15.81 and 18.44 mg) postoperatively compared with placebo (26.38 mg) (P<0.018). Patients receiving ropivacaine blocks localized pain in the posterolateral knee, whereas placebo block patients reported anteromedial and central pain. Other secondary outcomes were similar between groups.
Low volume saphenous-obturator block is significantly more effective than placebo in reducing both early and late pain-scores as well as postoperative opioid consumption in patients undergoing ACL-RC. No statistical difference existed when comparing low volume saphenous-obturator block to femoral-obturator block regarding early and late pain-scores and postoperative opioid consumption.
即使采用多模式镇痛方案,前交叉韧带重建(ACL-RC)后仍常伴有中重度术后疼痛。我们旨在比较小容量隐股入路阻滞与安慰剂及股隐入路阻滞在 ACL-RC 患者中的镇痛效果。
在一项随机对照试验中,82 例行 ACL-RC 伴腘绳肌腱自体移植的患者被分配至小容量隐股入路阻滞组、安慰剂阻滞组或股隐入路阻滞组。采用 0.75%罗哌卡因进行主动阻滞,生理盐水用于安慰剂。主要结局为术后 0-6 小时静息状态下疼痛评分的曲线下面积。次要结局为术后阿片类药物消耗和膝关节疼痛定位。
组间 6 小时疼痛评分的曲线下面积无统计学差异。然而,与安慰剂组相比,罗哌卡因组在苏醒即刻(t=0,P<0.018)、术后 5 分钟(t=5,P<0.042)和 6 小时(t=6,P<0.002)时疼痛评分显著降低。此外,与安慰剂组(26.38mg)相比,罗哌卡因阻滞组术后总阿片类药物消耗(15.81 和 18.44mg)显著减少(P<0.018)。接受罗哌卡因阻滞的患者将疼痛定位于膝关节后外侧,而接受安慰剂阻滞的患者报告膝关节前内侧和中央疼痛。其他次要结局在组间相似。
与安慰剂相比,小容量隐股入路阻滞可显著降低 ACL-RC 患者的早期和晚期疼痛评分以及术后阿片类药物消耗。在早期和晚期疼痛评分以及术后阿片类药物消耗方面,小容量隐股入路阻滞与股隐入路阻滞之间无统计学差异。