Fetterer R H
Comp Biochem Physiol A Comp Physiol. 1986;84(3):461-6. doi: 10.1016/0300-9629(86)90349-x.
The rate constants (K) for steroid transport across the isolated cuticle of Ascaris suum were, linearly related to partition coefficients (P) of steroids in model solvents. The slope of log P vs log K for an isolated cuticle was closest to unity for the more polar solvents, octanol and ether, suggesting that the barrier to steroid movement across the cuticle has partition properties similar to these solvents. The transcuticular movement of steroids into intact adult A. suum and infective larvae of Haemonchus contortus was predicted by the P in model solvents suggesting that the same barriers for transcuticular solute movement may exist in intact worms as in isolated cuticles.
类固醇穿过猪蛔虫离体角质层的速率常数（K）与类固醇在模型溶剂中的分配系数（P）呈线性相关。对于离体角质层，在极性更强的溶剂辛醇和乙醚中，log P与log K的斜率最接近1，这表明类固醇穿过角质层的屏障具有与这些溶剂相似的分配特性。模型溶剂中的分配系数（P）可预测类固醇在完整的成年猪蛔虫和捻转血矛线虫感染性幼虫中的经皮转运，这表明完整蠕虫中经皮溶质转运的屏障可能与离体角质层中的相同。
