Lamglait Benjamin, Lemberger Karin
J Zoo Wildl Med. 2017 Jun;48(2):491-496. doi: 10.1638/2016-0046R2.1.
This article reports five cases of colonic adenocarcinomas in a family group of captive Amur rat snake (Elaphe schrenckii) from the Réserve Africaine de Sigean, France. This tumor was detected in three females and two males, all adults, and accounted for 16% of causes of death of adults of this species at this institution from 1986 to 2013. Grossly, mild to marked thickening of the intestinal wall cranially to the cloaca was found in four cases; tan to yellow firm masses were noted in the distal intestinal wall in the other case. Microscopically, neoplasms were characterized by infiltrating, poorly circumscribed, and unencapsulated nests of epithelial cells. Marked anisokaryosis and anisocytosis were seen in all neoplasms. The etiology of the neoplasms was not determined, but the familial clustering suggests a common etiologic factor.
本文报道了来自法国西热非洲保护区圈养的黑龙江锦蛇（Elaphe schrenckii）家族群体中的5例结肠腺癌病例。该肿瘤在3只雌性和2只雄性成年蛇中被发现，占该机构1986年至2013年该物种成年蛇死亡原因的16%。大体上，4例病例在泄殖腔前方的肠壁出现轻度至明显增厚；另一例在远端肠壁发现棕褐色至黄色的坚实肿块。显微镜下，肿瘤的特征是上皮细胞巢浸润性生长、边界不清且无包膜。在所有肿瘤中均可见明显的核大小不等和细胞大小不等。肿瘤的病因尚未确定，但家族性聚集提示存在共同的病因因素。
