Xie Huijun, Tong Guihui, Zhang Yupei, Liang Shu, Tang Kairui, Yang Qinhe
College of Traditional Chinese medicine, Jinan University, Guangzhou 510632, China.
Department of Pathology, Guangdong Provincial Key Laboratory of Molecular Tumor Pathology and School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Int J Mol Sci. 2017 Jul 27;18(8):1630. doi: 10.3390/ijms18081630.
During the proliferation and metastasis, the tumor cells prefer glycolysis (Warburg effect), but its exact mechanism remains largely unknown. In this study, we demonstrated that phosphoglycerate kinase 1 (PGK1) is an important enzyme in the pathway of metabolic glycolysis. We observed a significant overexpression of PGK1 in hepatocellular carcinoma tissues, and a correlation between PGK1 expression and poor survival of hepatocellular carcinoma patients. Also, the depletion of PGK1 dramatically reduced cancer cell proliferation and metastasis, indicating an oncogenic role of PGK1 in liver cancer progression. Further experiments showed that PGK1 played an important role in -induced metabolic reprogramming, which led to an enhanced Warburg effect. Our results revealed a new effect of PGK1, which can provide a new treatment strategy for hepatocellular carcinoma, as PGK1 is used to indicate the prognosis of hepatocellular carcinoma (HCC).
在肿瘤细胞增殖和转移过程中，其更倾向于糖酵解（瓦伯格效应），但其确切机制在很大程度上仍不清楚。在本研究中，我们证明磷酸甘油酸激酶1（PGK1）是代谢糖酵解途径中的一种重要酶。我们观察到PGK1在肝细胞癌组织中显著过表达，且PGK1表达与肝细胞癌患者的不良生存之间存在相关性。此外，PGK1的缺失显著降低了癌细胞的增殖和转移，表明PGK1在肝癌进展中具有致癌作用。进一步的实验表明，PGK1在诱导的代谢重编程中起重要作用，这导致了增强的瓦伯格效应。我们的结果揭示了PGK1的一种新作用，由于PGK1可用于指示肝细胞癌（HCC）的预后，这可为肝细胞癌提供一种新的治疗策略。
Zotero 插件
