丝状肌动蛋白结合蛋白A（FLNA）和磷酸甘油酸激酶1（PGK1）是肝细胞癌进展的两个潜在标志物。

FLNA and PGK1 are two potential markers for progression in hepatocellular carcinoma.

作者信息

Ai Jianzhong, Huang Huizhe, Lv Xiaoyan, Tang Ziwei, Chen Mianzhi, Chen Tielin, Duan Weiwei, Sun Huan, Li Qingwei, Tan Ruizhi, Liu Yuhang, Duan Jingjing, Yang Yang, Wei Yuquan, Li Yan, Zhou Qin

机构信息

Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

出版信息

Cell Physiol Biochem. 2011;27(3-4):207-16. doi: 10.1159/000327946. Epub 2011 Apr 1.

DOI:10.1159/000327946

PMID:21471709

Abstract

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most deadly diseases; metastasis and recurrence are the most important factors that affect the therapy of HCC chronically. Until now, the prognosis for the metastasis of HCC had not improved. Recently, several proteins that are related to metastasis and invasion of HCC were identified, but the effective markers still remain to be elucidated.

METHODS

In this study, comparative proteomics was used to study the differentially expressed proteins in two HCC cell lines MHCC97L and HCCLM9, which have low and high metastatic potentials, respectively.

RESULTS

Our findings indicated that filamin A (FLNA) and phosphoglycerate kinase 1 (PGK1) were two significantly differentially expressed proteins, with high expression in HCCLM9 cells, and may influence the metastasis of HCC cells.

CONCLUSION

Taken together with the confirmation of expression on the mRNA level, we propose the use of FLNA and PGK1 as potential markers for the progression of HCC.

摘要

背景/目的：肝细胞癌（HCC）是最致命的疾病之一；转移和复发是长期影响HCC治疗的最重要因素。到目前为止，HCC转移的预后尚未得到改善。最近，几种与HCC转移和侵袭相关的蛋白质被鉴定出来，但有效的标志物仍有待阐明。