Ward Honorine D
Tufts Medical Center, Boston, MA 02111, USA.
Trends Parasitol. 2017 Sep;33(9):662-664. doi: 10.1016/j.pt.2017.07.004. Epub 2017 Jul 24.
The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves.
吡唑并吡啶类化合物KDU731是一种很有前景的候选药物，可用于治疗资源有限地区幼儿由隐孢子虫引起的腹泻。KDU731是一种磷脂酰肌醇-4激酶（PI(4)激酶）抑制剂，在体外和免疫功能低下小鼠的体内均能阻断隐孢子虫感染，并能显著减少新生小牛的卵囊排出、腹泻和脱水症状。
