Attwood D, Fletcher P
J Pharm Pharmacol. 1986 Jul;38(7):494-8. doi: 10.1111/j.2042-7158.1986.tb04621.x.
The aggregation characteristics of a series of local anaesthetic drugs in water and electrolyte solution have been examined using total intensity light scattering, photon correlation spectroscopy and vapour pressure osmometry. The association of cinchocaine hydrochloride was micellar. An appreciable increase in the effective diffusion coefficient as solutions of cinchocaine were diluted close to the critical micelle concentration was observed and has been discussed. The association of amethocaine hydrochloride could be described using a co-operative stepwise association model. No association could be detected in water or 0.1 mol dm-3 electrolyte for butacaine hemisulphate and the hydrochlorides of procaine, proparacaine, mepivacaine, lignocaine, bupivacaine and prilocaine at drug concentrations of less than 0.2 mol dm-3.
利用总强度光散射、光子相关光谱法和蒸气压渗透压法，研究了一系列局部麻醉药在水和电解质溶液中的聚集特性。盐酸辛可卡因的缔合为胶束状。当辛可卡因溶液稀释至接近临界胶束浓度时，观察到有效扩散系数有明显增加，并对此进行了讨论。盐酸丁卡因的缔合可用协同逐步缔合模型来描述。在药物浓度小于0.2mol/dm³时，丁卡因半硫酸盐以及普鲁卡因、丙美卡因、甲哌卡因、利多卡因、布比卡因和丙胺卡因的盐酸盐在水或0.1mol/dm³电解质中均未检测到缔合。
