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某些青霉素在水溶液中形成胶束的光散射研究。

Light scattering studies on micelle formation by some penicillins in aqueous solution.

作者信息

Attwood D, Agarwal S P

出版信息

J Pharm Pharmacol. 1984 Aug;36(8):563-4. doi: 10.1111/j.2042-7158.1984.tb04456.x.

Abstract

The aggregation of a number of penicillins, both in water and in electrolyte solution, has been examined by total intensity light scattering methods. Micellar association was noted for carfecillin, flucloxacillin cloxacillin, phenethicillin and penicillin V and critical micelle concentrations and micellar aggregation numbers were determined. Association of penicillin G in water and electrolyte was limited to dimer and trimer formation.

摘要

已通过总强度光散射法研究了多种青霉素在水和电解质溶液中的聚集情况。观察到羧苄青霉素、氟氯西林、氯唑西林、苯氧乙基青霉素和青霉素V存在胶束缔合现象,并测定了临界胶束浓度和胶束聚集数。青霉素G在水和电解质中的缔合仅限于形成二聚体和三聚体。

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