Murlas C
J Pharm Pharmacol. 1986 Jul;38(7):550-2. doi: 10.1111/j.2042-7158.1986.tb04637.x.
In unanaesthetized guinea-pigs, propranolol treatment (0.1 mg kg-1 i.v.) substantially increased reactivity to intravenous acetylcholine infusion or aerosolized histamine to a comparable degree. Neither BW755c (5 mg kg-1 i.v.), FPL 55712 (1 mg kg-1 i.v.), nor piriprost (5 mg kg-1 i.v.) pretreatment influenced propranolol's effect on muscarinic reactivity although BW755c abolished histaminic hyperreactivity. This suggests that propranolol-induced muscarinic hyperreactivity in the guinea-pig is not mediated by leukotrienes whereas histaminic hyperreactivity may be.
在未麻醉的豚鼠中，静脉注射普萘洛尔（0.1毫克/千克）可显著增强对静脉注射乙酰胆碱或雾化组胺的反应性，且程度相当。BW755c（静脉注射5毫克/千克）、FPL 55712（静脉注射1毫克/千克）或吡嘧司特（静脉注射5毫克/千克）预处理均未影响普萘洛尔对毒蕈碱反应性的作用，尽管BW755c消除了组胺高反应性。这表明豚鼠中普萘洛尔诱导的毒蕈碱高反应性不是由白三烯介导的，而组胺高反应性可能是由白三烯介导的。
