Montaño L M, Vargas M H, Páramo J I, Selman M E
Departamento de Fisiología y Farmacología, Facultad de Medicina Veterinaria y Zootecnia, UNAM, México, DF.
Pharmacol Res Commun. 1987 Dec;19(12):887-900. doi: 10.1016/0031-6989(87)90039-7.
In anesthetized guinea-pigs previously sensitized to ovalbumin by intratracheal immunization, the intravenous administration of propranolol (3.1 mg/kg) produced an increase in the respiratory insufflation pressure induced by ovalbumin. Atropine (2 mg/kg), zolertine (1 mg/kg) and indomethacin (3.1 mg/kg) did not antagonize the propranolol-induced airway hyperreactivity. Indomethacin at higher dose (10 mg/kg) and BW755c (10 mg/kg) decreased the potentiation of the respiratory insufflation pressure to ovalbumin. Our results suggest that besides the beta-blockade, propranolol-induced bronchial hyperreactivity to ovalbumin in sensitized guinea-pigs could be mediated by leukotrienes.
在通过气管内免疫预先对卵清蛋白致敏的麻醉豚鼠中，静脉注射普萘洛尔（3.1毫克/千克）会使卵清蛋白诱导的呼吸吹入压力增加。阿托品（2毫克/千克）、佐勒汀（1毫克/千克）和吲哚美辛（3.1毫克/千克）不能拮抗普萘洛尔诱导的气道高反应性。较高剂量的吲哚美辛（10毫克/千克）和BW755c（10毫克/千克）可降低对卵清蛋白的呼吸吹入压力增强作用。我们的结果表明，除了β受体阻滞作用外，普萘洛尔诱导的致敏豚鼠对卵清蛋白的支气管高反应性可能由白三烯介导。
