Asero Riccardo, Tedeschi Alberto, Marzano Angelo Valerio, Cugno Massimo
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (Milano), Italy.
Ambulatorio di Allergologia e Immunologia Clinica, Ospedale Fatebenefratelli e Oftalmico, Milano, Italy.
F1000Res. 2017 Jul 11;6:1095. doi: 10.12688/f1000research.11546.1. eCollection 2017.
Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality of life and sometimes represent a challenge for doctors as well. The causes of chronic urticaria are still poorly defined, although there is growing evidence that different biologic systems including immunity, inflammation, and coagulation may take part in the pathomechanism eventually leading to mast cell and basophil degranulation and hence to wheal formation. This review will discuss the main findings that are (slowly) shedding light on the pathogenesis of this disorder.
慢性荨麻疹是一组自发性或诱发性疾病，其特征为风团（约半数病例伴有血管性水肿）出现超过6周。这些病症相当常见，可能严重影响患者的生活质量，有时对医生来说也是一项挑战。尽管越来越多的证据表明，包括免疫、炎症和凝血在内的不同生物系统可能参与最终导致肥大细胞和嗜碱性粒细胞脱颗粒从而形成风团的发病机制，但慢性荨麻疹的病因仍未明确。本综述将讨论（正在缓慢地）阐明该疾病发病机制的主要研究结果。
