消融放疗作为心律失常导管消融的非侵入性替代方法
Ablative Radiotherapy as a Noninvasive Alternative to Catheter Ablation for Cardiac Arrhythmias.
作者信息
Zei Paul C, Soltys Scott
机构信息
Department of Medicine, Electrophysiology Section, Brigham and Women's Hospital, 70 Francis Street, Shapiro Building - Room 05088, Boston, MA, 02115, USA.
Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
出版信息
Curr Cardiol Rep. 2017 Sep;19(9):79. doi: 10.1007/s11886-017-0886-2.
PURPOSE OF REVIEW
Stereotactic radioablation is a commonly utilized technology to noninvasively treat solid tumors with precision and efficacy. Using a robotic arm mounted delivery system, multiple low-dose ionizing radiation beams are delivered from multiple angles, concentrating ablative energy at the target tissue. Recently, this technology has been evaluated for treatment of cardiac arrhythmias. This review will present the basic underlying principles, proof-of-principle studies, and clinical experience with stereotactic arrhythmia radioablation.
RECENT FINDINGS
Most recently, stereotactic radioablation has been used to safely and effectively treat a limited number of patients with malignant arrhythmias, including ventricular tachycardia (VT) and atrial fibrillation (AF). Treatment protocols, outcomes, ongoing studies, and future directions will be discussed. Stereotactic radioablation is a well-established technology that has been shown to be a safe and effective therapy for patients with drug-refractory cardiac arrhythmias, including VT and AF. Further clinical evaluation to define safety and efficacy in larger populations of patients is needed.
综述目的
立体定向放射消融是一种常用技术，可精确且有效地无创治疗实体瘤。通过安装在机器人手臂上的递送系统，从多个角度发射多束低剂量电离辐射束，将消融能量集中于靶组织。最近，该技术已被评估用于治疗心律失常。本综述将介绍立体定向心律失常放射消融的基本原理、原理验证研究及临床经验。
最新发现
最近，立体定向放射消融已被用于安全有效地治疗少数恶性心律失常患者，包括室性心动过速（VT）和心房颤动（AF）。将讨论治疗方案、结果、正在进行的研究及未来方向。立体定向放射消融是一项成熟技术，已被证明对包括VT和AF在内的药物难治性心律失常患者是一种安全有效的治疗方法。需要进一步进行临床评估以确定在更大患者群体中的安全性和有效性。
Zotero 插件