Mercy Health Osteoporosis and Bone Health Services, 4760 E. Galbraith Rd., Suite 212, Cincinnati, OH, 45236, USA.
Osteoporos Int. 2017 Oct;28(10):2741-2746. doi: 10.1007/s00198-017-4171-4. Epub 2017 Jul 27.
There is a growing list of medications used to treat non-skeletal disorders that cause bone loss and/or increase fracture risk. This review discusses glucocorticoids, drugs that reduce sex steroids, antidiabetic agents, acid-reducing drugs, selective serotonin reuptake inhibitors, and heparin. A number of drugs are known to cause bone loss, increase fracture risk, or both. These drugs should be used in the lowest dose necessary to achieve the desired benefit and for the shortest time necessary, but in many cases, long-term treatment is required. Effective countermeasures are available for some.
用于治疗非骨骼疾病的药物越来越多，这些疾病会导致骨质流失和/或增加骨折风险。本综述讨论了糖皮质激素、降低性激素的药物、抗糖尿病药物、胃酸抑制药物、选择性 5-羟色胺再摄取抑制剂和肝素。许多药物已知会导致骨质流失、增加骨折风险或两者兼有。这些药物应在达到预期疗效所需的最低剂量和最短时间内使用，但在许多情况下，需要长期治疗。一些药物已经有了有效的对策。
