Wystub N, Heymel S, Fritzenwanger M, Schulze P C, Pfeifer R
Klinik für Innere Medizin I, Universitätsklinikum Jena, Am Klinikum 1, 07747, Jena, Deutschland.
Med Klin Intensivmed Notfmed. 2018 Apr;113(3):212-216. doi: 10.1007/s00063-017-0325-6. Epub 2017 Jul 27.
Neuroleptic malignant syndrome (NMS) is a rare disorder caused by drug-induced dopamine-receptor-blockage or low dopamine concentration in the brain. It is a severe reaction to neuroleptic drugs in antipsychotic therapy. Symptoms in NMS typically consist of fever, muscle rigidity and cognitive changes; laboratory findings include elevated infectious disease markers and creatine kinase as well as signs of rhabdomyolysis. To differentiate NMS from other malignant hyperthermia syndromes identifying the offending drug and clinical history are essential. Therapy in NMS includes withdrawal of the causative medication and intensive care treatment possibly with administration of dantrolene.In this case report, we describe the clinical course of a 48 year old man who developed typical clinical symptoms and laboratory parameters of malignant hyperthermia syndrome after injection of haloperidol.
神经阻滞剂恶性综合征（NMS）是一种由药物引起的多巴胺受体阻滞或大脑中多巴胺浓度降低所致的罕见病症。它是抗精神病治疗中对神经阻滞剂药物的严重反应。NMS的症状通常包括发热、肌肉强直和认知改变；实验室检查结果包括传染病标志物和肌酸激酶升高以及横纹肌溶解的迹象。为了将NMS与其他恶性高热综合征区分开来，确定致病药物和临床病史至关重要。NMS的治疗包括停用致病药物以及可能使用丹曲林进行重症监护治疗。在本病例报告中，我们描述了一名48岁男性在注射氟哌啶醇后出现恶性高热综合征典型临床症状和实验室参数的临床过程。
