Department of Psychiatry, Taichung Veterans General Hospital, 40705, Taiwan.
Gen Hosp Psychiatry. 2012 Jul-Aug;34(4):436.e5-7. doi: 10.1016/j.genhosppsych.2012.01.016. Epub 2012 Mar 27.
Venlafaxine is a relatively new antidepressant with selective effects. Compared with traditional antidepressants, this agent has fewer adverse side effects. However, venlafaxine overdose has been reported with severe complications such as seizure, ventricular tachycardia, serotonin syndrome, neuroleptic malignant syndrome and rhabdomyolysis. We present a 21-year-old female with bipolar depression who took a low dose of venlafaxine, but subsequently developed severe rhabdomyolysis. Her plasma level of creatine kinase increased up to 18,711 U/L in few days. These findings may serve as a reminder to physicians to be alert to the possibility of rhabdomyolysis in patients who have only taken a low dose of venlafaxine.
文拉法辛是一种具有选择性作用的相对较新的抗抑郁药。与传统的抗抑郁药相比，这种药物的不良反应较少。然而，已有文拉法辛过量的报道，伴有严重并发症，如癫痫发作、室性心动过速、血清素综合征、恶性神经阻滞剂综合征和横纹肌溶解症。我们报告了一位 21 岁的女性双相抑郁症患者，她服用了低剂量的文拉法辛，但随后出现严重的横纹肌溶解症。她的肌酸激酶血浆水平在几天内升高到 18711 U/L。这些发现可能提醒医生注意仅服用低剂量文拉法辛的患者发生横纹肌溶解症的可能性。
